Anaesthetics - Pharmacology

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5 Cards. Created by Beth Smithson ().

Partition coefficient

The ratio of the amount of substance in one phase to the amount of it in another at a stated temperature, when the two phases are in equilibrium and of equal volumes and pressures

Blood:gas coefficient

a measure of the solubility of a substance in the blood and influences anaesthetic onset and offset times. More soluble = slower onset and offset times (higher BG part coeff). Poorly soluble (low BG CP) = increased speed of equilibration = faster onset/offset Shown by washin curves

Oil:gas coefficient

A measure of lipid solubility and is an indicator of potency. It is inversely related to MAC. Highly lipid soluble = more potent and lower MAC. Meyer-Overton hypothesis


Minimum alveolar concentration, at equilibrium (15 mins of inhalation), at sea level, in 100% O2, at which 50% of the population will fail to respond to standard noxious stimulus. This is MAC50. Stimulus refers to a standard surgical skin incision, and the response refers to purposeful muscular movement


MAC awake

MAC intubation

Concentration required to prevent movement in 90% of subject

0.3-0.4 MAC - at which eyes open on verbal command during emergence from anaesthesia

MAC intubation - 1.3 MAC and is the MAC required to prevent coughing and movement during endotracheal intubation